Diagnostic validity of tertiary lymphoid structure (TLS) evaluation using transbronchial cryobiopsy (TBCB) specimens in non-small cell lung cancer: A retrospective study comparing with surgical specimens

Validation of tertiary lymphoid structure (TLS) evaluation using transbronchial cryobiopsy (TBCB) specimens in non-small cell lung cancer: A retrospective study comparing with surgical specimens - Cryo-TLS study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000060799

Enrollment

Registered

2026-03-10

Start date

2026-01-15

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-small cell carcinoma

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with non-small cell lung cancer who underwent transbronchial cryobiopsy (TBCB) for preoperative diagnosis at our hospital Patients who subsequently underwent surgical resection of the primary lesion Patients whose medical records and preserved pathological specimens (paraffin blocks) are available for analysis

Exclusion criteria

Exclusion criteria: Cases with insufficient specimen volume for pathological evaluation (presence and maturity of TLS) Cases that received preoperative chemotherapy or radiotherapy Other cases deemed inappropriate for this study by the principal investigator

Design outcomes

Primary

Measure	Time frame
Concordance rate and Cohen's Kappa coefficient of tertiary lymphoid structure (TLS) evaluation (Positive/Negative) between transbronchial cryobiopsy (TBCB) specimens and surgical specimens	—

Countries

Japan

Contacts

Public ContactToshiyuki Sumi

Hakodate Goryoukaku Hospital Respiratory medicine

tsh715@gmail.com0138-51-2295

Outcome results