Nocturnal enuresis
Conditions
Interventions
Participants will receive cranberry extract supplement (5 tablets) once daily for 3 weeks.
Participants will receive placebo (5 tablets) once daily for 3 weeks.
Sponsors
Kansai Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Children aged 5 to 15 years at the time of consent. 2) Outpatients. 3) Gender: Both male and female. 4) Diagnosed with nocturnal enuresis. 5) Patients from whom written informed consent has been obtained from the participant or their legal guardian after sufficient explanation and understanding.
Exclusion criteria
Exclusion criteria: Children who meet any of the following criteria: 1) Use of antibiotics within the last month. 2) Routine consumption of cranberries or cranberry products. 3) Presence of underlying renal or urinary tract diseases. 4) Refusal to participate in this study. 5) Otherwise judged unsuitable for the study by the principal investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relative abundance of urinary microbiota | — |
Secondary
| Measure | Time frame |
|---|---|
| Diversity of urinary microbiota Urine pH Hippuric acid concentration in urine Frequency of nocturnal enuresis Frequency of daytime urinary incontinence Maximum voided volume Fecal organic acid concentration Gut microbiota diversity and functional prediction Nocturnal urine volume | — |
Countries
Japan
Contacts
Public ContactShohei Akagawa
Kansai Medical University Hospital Department of Pediatrics
Outcome results
None listed