Effects of Nostoc commune hot-water extract intake on salivary IgA in healthy adults

Effects of hot-water extract of edible cyanobacteria Nostoc commune on salivary secretory IgA: a randomized crossover trial - NOSTOC-sIgA Trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000060752

Enrollment

Registered

2026-02-28

Start date

2026-03-05

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy adults (mucosal immunity assessment)

Interventions

Participants ingest 100mL of a beverage made by extracting 1g of Nostoc with 100mL of hot water. After an overnight fast, salivary samples are collected repeatedly up to 120 minutes post-intake. A 6-d

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy adults aged 18 years or older Students or staff at Kitasato University Sagamihara campus Provided written informed consent

Exclusion criteria

Exclusion criteria: Allergy to Nostoc commune components Fever 37.5 C or higher Regular medication use Immunodeficiency anticoagulant therapy or significant underlying disease

Design outcomes

Primary

Measure	Time frame
Change in salivary secretory immunoglobulin A (sIgA) concentration measured at baseline and 10, 30, 60, 90, and 120 minutes after intake	—

Secondary

Measure	Time frame
Lifestyle questionnaire including smoking, alcohol intake, and physical activity Sleep status assessed using the Japanese version of the Pittsburgh Sleep Quality Index (PSQI) Adverse events monitoring	—

Countries

Japan

Contacts

Public ContactTadahiro Suenaga

Kitasato University Department of Immunology, Kitasato University School of Medicine

suenaga.tadahiro@kitasato-u.ac.jp042-778-8025

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Sep 19, 2026