Development of MR Cine Sialography for the Evaluation of Salivary Gland Function

Development of MR Cine Sialography for the Evaluation of Salivary Gland Function - Development of MR Cine Sialography for the Evaluation of Salivary Gland Function

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000060736

Enrollment

120

Registered

2026-02-23

Start date

2025-05-19

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sjogren&#39

Interventions

MRI will be used to noninvasively visualize salivary flow without contrast agents. The examination will be performed once, with a total scan time of approximately 30 minutes. During the examination, c

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy volunteers; patients with reduced salivary secretion; patients with Sjogren's syndrome; and patients with head and neck malignancies before and after radiotherapy.

Exclusion criteria

Exclusion criteria: Individuals with MRI-incompatible metallic implants; individuals with severe claustrophobia; and individuals who request discontinuation of the examination.

Design outcomes

Primary

Measure	Time frame
Salivary flow visualized by MR cine sialography (MRCS) will be scored, and the following evaluations will be performed: 1. Correlation analysis between MRCS scores and salivary volume measured by the spitting method and gum-chewing test in healthy volunteers. 2. Comparison of MRCS scores between normal subjects and patients with Sjogren's syndrome (SS). 3. Association analysis between MRCS scores and diagnostic parameters included in the Japanese clinical guidelines, including labial salivary gland biopsy findings, oral examination results, ophthalmologic test results, serologic markers, and unstimulated salivary volume. 4. Comparative evaluation of MRCS with conventional MR sialography and structural MRI.	—

Measure

Time frame

Salivary flow visualized by MR cine sialography (MRCS) will be scored, and the following evaluations will be performed: 1. Correlation analysis between MRCS scores and salivary volume measured by the spitting method and gum-chewing test in healthy volunteers. 2. Comparison of MRCS scores between normal subjects and patients with Sjogren's syndrome (SS). 3. Association analysis between MRCS scores and diagnostic parameters included in the Japanese clinical guidelines, including labial salivary gland biopsy findings, oral examination results, ophthalmologic test results, serologic markers, and unstimulated salivary volume. 4. Comparative evaluation of MRCS with conventional MR sialography and structural MRI.

—

Countries

Japan

Contacts

Public ContactTatsuya Koizumi

Juntendo University Hospital Department of Radiology

t.koizumi.zb@juntendo.ac.jp03-3813-3111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026