Identification of oral bacteria involved in mild cognitive impairment and research on methods for controlling them

Identification of oral bacteria involved in mild cognitive impairment and research on methods for controlling them - Oral bacteria involved in mild cognitive impairment

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000060727

Enrollment

225

Registered

2026-03-01

Start date

2020-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild cognitive impairment

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Patient group: 1) Diagnosed with mild cognitive impairment according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) by the American Psychiatric Association, and 2) scored 25 or below on the Montreal Cognitive Assessment (MoCA)-J, which evaluates multiple cognitive functions, and 20 or above on the Mini Mental State Examination (MMSE)-J. (2) Control group: Outpatients of the Department of Oral and Maxillofacial Surgery at our hospital with normal cognitive function (MoCA score 26 points or more, MMSE-J score 28 points or more).

Exclusion criteria

Exclusion criteria: 1) History of head trauma, brain tumors, or neurodegenerative diseases. 2) For the patient group, outpatient primary care physicians have already prescribed anti-dementia drugs, steroids, or antibiotics that affect oral bacteria.

Design outcomes

Primary

Measure	Time frame
Whether dementia developed during the observation period	—

Secondary

Measure	Time frame
Depression, anxiety, motivation, happiness, daily life intensity	—

Countries

Japan

Contacts

Public ContactToshio Matsubara

Yamaguchi University Graduate School of Medicine Division of Neuropsychiatry, Department of Neuroscience

t-matsu@yamaguchi-u.ac.jp0836222255

Outcome results