Study on the safety and efficacy of different application methods (intermittent vs 24-hour) of blonanserin patch in hospitalized patients

Retrospective comparative observational study on the effects of intermittent versus 24-hour application of blonanserin transdermal patches on delirium events and daytime over-sedation in hospitalized patients - Comparative study of intermittent vs 24-hour blonanserin patch

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000060648

Enrollment

140

Registered

2026-02-11

Start date

2026-02-11

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Delirium

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Inpatients at Kyoto University Hospital (from January 1, 2020, to December 31, 2024). 2. Aged 65 years or older. 3. Patients who started blonanserin transdermal patches for either prevention or treatment of delirium.

Exclusion criteria

Exclusion criteria: Patients who were already receiving regular administration of antipsychotics or high-potency sedatives at the time of admission.

Design outcomes

Primary

Measure	Time frame
Incidence of daytime over-sedation during the first 3 days after initiation (percentage of patients with at least one record of RASS -2 or lower based on nursing records or RASS scores between 8:00 and 21:00).	—

Secondary

Measure	Time frame
1. Delirium cure rate at Day 2 (in the cohort with delirium). 2. Delirium incidence/recurrence rate by Day 2 (in the cohort without delirium). 3. Rate of change or discontinuation of the application strategy. 4. Rate of new addition or dose increase of other psychotropics or sedatives.	—

Countries

Japan

Contacts

Public ContactYudai Takatani

Kyoto University Hospital Department of Primary Care and Emergency Medicine

takataniyu@kuhp.kyoto-u.ac.jp075-751-4210

Outcome results