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Heterogeneous Treatment Effects of Early High-Dose Rehabilitation in Acute Ischemic Stroke: Target Trial Emulation and Causal Forests

Heterogeneous Treatment Effects of Early High-Dose Rehabilitation in Acute Ischemic Stroke: Target Trial Emulation and Causal Forests - Heterogeneous Treatment Effects of Early High-Dose Rehabilitation in Acute Ischemic Stroke

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000060567
Enrollment
40000
Registered
2026-04-30
Start date
2026-02-22
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic Stroke

Interventions

None listed

Sponsors

Mie University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Eligibility criteria were as follows: (1) ischemic stroke (ICD-10: I63*) identified in the DPC data as either the reason for admission or the principal diagnosis; (2) age >= 18 years; (3) pre-admission modified Rankin Scale (mRS) score <= 4; and (4) confirmed stay in a stroke care unit (SCU) on the day of admission (Day 1-SCU). Time zero was defined as the admission date (Day 1). Day 1-SCU was identified using a claims-based proxy definition: the first billing date of an SCU-related management fee in the DPC data coinciding with the admission date.

Exclusion criteria

Exclusion criteria: Exclusion criteria were: (1) cases suggestive of in-hospital onset; (2) cases with clear evidence of long-term care (LTC) residence prior to admission; and (3) cases with an explicit contraindication to rehabilitation immediately after admission (e.g., immediately after decompressive craniectomy, ventricular drainage/external ventricular drain [EVD] placement, initiation of extracorporeal membrane oxygenation [ECMO], or initiation of high-dose vasopressors).

Design outcomes

Primary

MeasureTime frame
Barthel Index at discharge

Secondary

MeasureTime frame
modified Rankin Scale (mRS) score at discharge (including achievement of mRS 0-3)

Countries

Japan

Contacts

Public ContactHirofumi Nagayama

Kanagawa University of Human Services Department of Occupational therapy, The School of Rehabilitation

nagayama-ktr@kuhs.ac.jp046-828-2724

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Sep 19, 2026