Investigation of the Relationship Between Endothelial Function and Autonomic Nervous Function in Patients with Diabetes: A Retrospective Observational Study Using FMD and CVRR

A Retrospective Observational Study Evaluating the Association Between Flow-Mediated Dilation (FMD) and the Coefficient of Variation of R-R Intervals (CVRR) in Patients with Diabetes - Correlation Study of FMD and CVRR

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000060540

Enrollment

Registered

2026-01-31

Start date

2025-09-25

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes mellitus

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients diagnosed with diabetes mellitus Patients who underwent both FMD and CVRR measurements Patients with required clinical data available in the electronic medical record

Exclusion criteria

Exclusion criteria: Patients without available FMD or CVRR data

Design outcomes

Primary

Measure	Time frame
Correlation between flow-mediated dilation (FMD) and the coefficient of variation of R-R intervals (CVRR), using measurement data obtained within 3 months of the FMD examination.	—

Secondary

Measure	Time frame
Evaluation of the associations between FMD and CVRR and various clinical background factors, including age, sex, BMI, HbA1c, lipid parameters, blood pressure, CAVI, diabetic retinopathy, neuropathy, nephropathy, and endocrine markers.	—

Countries

Japan

Contacts

Public ContactTakanobu Saheki

Kagawa University Hospital Department of Clinical Laboratory

saheki.takanobu@kagawa-u.ac.jp087-891-2230

Outcome results