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Clinicopathological Analysis of Renal Fibrosis-Related Molecules Using Human Kidney Biopsy Specimens

Clinicopathological Analysis of Renal Fibrosis-Related Molecules Using Human Kidney Biopsy Specimens - Clinicopathological Analysis of Renal Fibrosis-Related Molecules Using Human Kidney Biopsy Specimens

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000060539
Enrollment
500
Registered
2026-06-01
Start date
2026-06-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Kidney Disease (CKD)

Interventions

None listed

Sponsors

Saitama Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Eligible participants are adult patients (>=18 years old) with chronic kidney disease, regardless of sex, who are judged by the principal or co-investigators to fulfill all of the following criteria: Diagnosed with a major renal disease such as diabetic kidney disease, nephrosclerosis, or IgA nephropathy. Kidney biopsy specimens have been appropriately fixed and preserved, allowing for immunohistochemical assessment. Clinical laboratory data are documented in the electronic medical records.

Exclusion criteria

Exclusion criteria: Cases where immunohistochemical evaluation is not feasible due to insufficient biopsy specimen quantity or inadequate preservation. Cases with significant gaps in follow-up data that prevent assessment of renal function progression. Cases with an unconfirmed or unclassifiable histopathological diagnosis (cases potentially requiring future re-evaluation of kidney biopsy findings are excluded from this study).

Design outcomes

Primary

MeasureTime frame
Association between expression levels of glucose metabolism-related molecules by immunostaining, fibrosis indices, and eGFR slope

Countries

Japan

Contacts

Public ContactHirokazu Okada

Saitama Medical University Hospital Department of Nephrology

okada.hirokazu@1972.saitama-med.ac.jp049-276-1611

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026