chronic periodontitis, moderate to severe
Conditions
Interventions
Use of tranexamic acid mouthwash
Use of benzethonium chloride Mouthwash
Sponsors
Nihon University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The study population consists of patients aged 20 years or older with Stage III-IV periodontitis who visited the Periodontology Department at Nihon University Matsudo Dental Hospital. Selection criteria for subjects were based on re-evaluation findings after subgingival SRP under local anesthesia and radiographic evaluation of vertical intrabony defects with bone loss depth more than 3mm and pocket depth (PD) more than 5mm. Subjects had to consent to undergoing periodontal tissue regeneration therapy (REGROTH).
Exclusion criteria
Exclusion criteria: 1.Smokers 2.Patients with uncontrolled diabetes 3.Those with acute symptoms 4.Those taking medications that may affect periodontal tissues (e.g., phenytoin, nifedipine, cyclosporine A) 5.Pregnant or breastfeeding individuals 6.Those with a history of oral cancer 7.Those with alcohol hypersensitivity.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical attachment gain at postoperative 6 month | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain assessment at postoperative 2, 7, 14 day, qPCR for bacteria at postoperative 7, 14 day, bone filling and reduction of probing depth at postoperative 6 month | — |
Countries
Japan
Contacts
Public ContactYohei Nakayama
Nihon University School of Dentistry at Matsudo Department of periodontology
Outcome results
None listed