Periodontal disease
Conditions
Interventions
Use of CPC + beta-glycyrrhetinic acid paste and liquid formulations at least twice daily for 3 months.
Use of chlorhexidine-containing paste and CHX + MAG liquid formulation at least twice daily for 3
Sponsors
Aichi Gakuin University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Patients who have received explanations about the purpose, content, and side effects of this study, fully understood them, voluntarily wished to participate in the study, and provided written informed consent (2) Patients who have 16 or more remaining teeth (3) Patients who have stable teeth with a PPD of 4-8mm, excluding third molars (4) Patients who are 20 years of age or older at the time of obtaining consent
Exclusion criteria
Exclusion criteria: (1) Patients who have been administered antibiotics (antimicrobial agents) within 1 month before the start of the study (2) Patients currently being treated for cancer, stroke, acute myocardial infarction, diabetes, or autoimmune diseases (3) Pregnant or breastfeeding individuals (4) Smokers (5) Patients who have experienced allergic reactions to toothpaste in the past (6) Patients who are visiting a dental clinic and receiving treatment for oral diseases other than periodontal disease (7) Patients currently participating in other clinical trials related to oral health
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Levels of active MMP-8 in gingival crevicular fluid (GCF) and salivary microbiota composition | — |
Secondary
| Measure | Time frame |
|---|---|
| Probing pocket depth (PPD), clinical attachment level (CAL), bleeding on probing (BOP), plaque index (PlI), and IL-1beta levels in GCF | — |
Countries
Japan
Contacts
Public ContactHisashi Goto
School of Dentistry, Aichi Gakuin University Department of Periodontology
Outcome results
None listed