Healthy Adults
Conditions
Interventions
Participants gargle with 15 mL of Test Solution A twice daily (after waking up and before bedtime) for at least 30 seconds for a period of 2 weeks. Following a 1-week washout period, they gargle with
Sponsors
BIOSIS Lab. Co., Ltd.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Persons who received a sufficient explanation of the purpose and contents of the research, have the capacity to consent, applied with free will with sufficient understanding, and agreed to participate 2.Persons who are Japanese citizens, aged 20 or older and under 65 at the time of consent
Exclusion criteria
Exclusion criteria: 1.Persons who have systemic diseases (such as severe heart disease, renal disease, or hepatic dysfunction) and are receiving medical treatment, or those with a history of such diseases. 2.Persons who have severe oral diseases (such as stomatitis or advanced dental caries) that are judged by the investigator as likely to affect the study outcomes. 3.Persons who have a history of using antibiotics, steroids, or anti-inflammatory drugs within one week prior to saliva collection. 4.Persons who regularly use medications or Food with Health Claims (including Food for Specified Health Uses (FOSHU), Food with Function Claims, and Food with Nutrient Function Claims) that may affect the oral environment. 5.Persons who are at risk of developing allergies related to the test foods 6.Persons who regularly use the test solution on a routine basis. 7.Persons who are judged unsuitable as research subjects based on their responses to a background survey 8.Persons who have participated in other research during one month prior to the start of this research, or plan to participate in other research after consenting to this research. 9.Persons who are breastfeeding, pregnant, or have plans to become pregnant during the study period 10.Persons who are judged to be ineligible by the principal investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oral microbiome | — |
Secondary
| Measure | Time frame |
|---|---|
| Subjective symptoms reported by participants (swelling, bleeding, halitosis; assessed via questionnaire), Probing Pocket Depth (PPD), Clinical Attachment Level (CAL), Bleeding on Probing (BOP), Plaque Index (PI), Gingival status around implants (Gingival Index: GI), Fecal microbiome, Measurement of Colony Forming Units (CFU), Salivary mucin levels | — |
Countries
Japan
Contacts
Public ContactTakumi Tochio
BIOSIS Lab. Co., Ltd. CEO
Outcome results
None listed