Molecular subtyping of autism spectrum disorder using whole-cortex omics analysis

Investigation of autism spectrum disorder subtypes using whole-cortex level omics analysis - ASD whole-cortex omics

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000060273

Enrollment

165

Registered

2026-01-06

Start date

2024-07-22

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autism spectrum disorder (ASD)

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Anonymized existing data of individuals diagnosed with autism spectrum disorder (ASD) and healthy controls stored in the PsychENCODE Knowledge Portal managed by the NIMH Repository and Genomics Resource (NRGR), with available diagnostic assessments such as ADI-R and ADOS.

Exclusion criteria

Exclusion criteria: Cases lacking sufficient diagnostic information or having medical or genetic conditions deemed to substantially affect the validity of the analyses.

Design outcomes

Primary

Measure	Time frame
Identification of molecular subtypes of ASD based on cortical multi-omics profiles (clustering-derived subtype classification).	—

Secondary

Measure	Time frame
(1) Differential molecular features among subtypes (gene expression, ATAC-seq, histone acetylation, DNA methylation, miRNA, etc.) (2) Associations between subtypes and clinical/behavioral measures (e.g., ADI-R, ADOS, IQ).	—

Countries

Japan

Contacts

Public ContactNoritaka Ichinohe

National Center of Neurology and Psychiatry Department of Ultrastructural Research, National Institute of Neuroscience

nichinohe72@gmail.com0423461719

Outcome results