Blood-based metabolic changes in long-term survivors with chronic carbon monoxide poisoning sequelae

Serum Metabolomic Signature and Brain-Derived Neurotrophic Factor in Long Term Survivors with Chronic Sequelae of Carbon Monoxide Poisoning 60 Years after the Miike Mikawa Coal Mine Disaster: A Cross-Sectional Case Control Study - MIKE-CO60

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000060244

Enrollment

Registered

2026-01-03

Start date

2024-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with Chronic Sequelae of Carbon Monoxide Poisoning

Interventions

None listed

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Age >= 75 years at enrollment. Former coal miners who worked at the Miike-Mikawa coal mine (Omuta, Japan) around the time of the 9 November 1963 coal dust explosion. CO group: Outpatients with chronic sequelae of carbon monoxide (CO) poisoning accompanied by higher brain dysfunction and followed under the workers' compensation-based aftercare program. Control (CON) group: Former miners from the same mine with no disaster-related CO exposure and not followed for CO-poisoning sequelae.

Exclusion criteria

Exclusion criteria: Neuropsychiatric disorders not attributable to CO-poisoning sequelae. History of cerebrovascular disease with evident residual paralysis and/or persistent cognitive impairment. For the serum metabolomics analysis subset: current use of medications that could materially affect energy metabolism, including (a) antidiabetic agents, (b) thyroid-related medications (thyroid hormone replacement or antithyroid drugs), or (c) systemic oral corticosteroids.

Design outcomes

Primary

Measure	Time frame
Between-group differences (CO vs. CON) in serum concentrations of the predefined key metabolites measured by targeted metabolomics	—

Secondary

Measure	Time frame
Inter-metabolite correlations among the predefined key metabolites measured by targeted serum metabolomics. Correlations between the predefined key metabolites and physical/cognitive functional measures (e.g., FIM-cognitive, LSA, MMSE, CBA, TMT-B, BMI, SMI).	—

Countries

Japan

Contacts

Public ContactAyumi Imafuku

Kurume University Industry Academia Government Collaboration Promotion Office, Department of Strategic Planning

sangaku@kurume-u.ac.jp08049057194

Outcome results