Adult
Conditions
Interventions
Blood samples are collected up to 8 hour after ingestion of each of four formulations. The experimental periods are separated by at least 72 hours as a washout period.
Sponsors
Yamada Bee Company, Inc.
Gifu Pharmaceutical university.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Healthy Japanese men and women aged between 20 and 50 at the time of informed consent. 2. BMI:18.5 - 25.0
Exclusion criteria
Exclusion criteria: 1. Participants who have history of food allergies. 2. Participants who have history of asthma. 3. Participants in pregnancy or in nursing. 4. Participants who are enrolled in another clinical trial during this study. 5. Participants who have a history of the surgery considerable in the gastrointestinal tract site, for example, gastrectomy, gastrointestinal suturing, intestinal resection and so on. 6. Participants with a current or history of serious illness, such as diabetes, liver disease, kidney diseases, heart diseases, and more. 7. Participants who have taken medication treatment. 8. Participants who can not refrain from consuming for specified foods from dinner on the night before the test until the end of the test. 9. Participants who can not quit smoking from dinner on the night before the test until the end of the test. 10. Participants who are unable to consume the test food as instructed or remain at rest until the completion of the study. 11. Participants who can not prohibit intake of foods, medicines, and supplements containing propolis or flavonoid at least one week prior to the start of this study. 12. Participants who can not continue regular life. 13. Participants who are night workers of shift workers. 14. Participants who have taken the blood sampling either 200 mL within 4 weeks or 400 mL within 3 months. 15. Participants who are heavy drinker ( >500 mL beer per day ) . 16. Participants who are smoking more than 20 cigarettes per day. 17. Participants who are judged as unsuitable for the current in this study by the study director.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma concentration and the area under the plasma concentration -time curve of Artepillin C | — |
Countries
Japan
Contacts
Public ContactYuki Haruna
Yamada Bee Company, Inc. Functional Ingredient research section, Institute for Bee product & Health Science, R&D department.
Outcome results
None listed