Healthy Adults
Conditions
Interventions
Phase1(Control Food),Washout,Phase2(Test Food)
Phase1(Test Food),Washout,Phase2(Control Food)
Sponsors
Mitsubishi Corporation Life Sciences Limited
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Individuals who have received a full explanation of the purpose and content of this study,are competent to consent,fully understand the content,voluntarily volunteer to participate,and can provide written consent to participate in this study. 2.Men and women aged 35 years or older at the time of consent. 3.Individuals deemed appropriate for participation in this study by the principal investigator. 4.From among those who meet the above criteria,priority will be given to individuals concerned about skin aging spots (those deemed appropriate for this study by the principal investigator after reviewing images of the applicant's aging spots).
Exclusion criteria
Exclusion criteria: 1.Subjects with a current or past serious illnesses,including brain disease,malignant tumors,immune disorders,diabetes,liver disease (hepatitis),liver damage,kidney disease,heart disease,thyroid disease,adrenal gland disease,or other metabolic disorders. 2.Subjects currently undergoing treatment for psychiatric disorders,including sleep disorders (insomnia) and depression. 3.Subjects who may have allergic reactions to the test food (vitamins),supplements,and ingredients in the test food and placebo foods,as well as to other foods and medications. 4.Subjects who are not using topical preparations or foods (including those containing NMN or N-methyl-N ... Individuals who are unable to refrain from using or consuming any of the following substances from two weeks prior to or during the study: D+ precursors,niacin (vitamin B3,nicotinamide,nicotinamide), glutathione,cysteine,yeast extract,vitamin C,vitamin E,vitamin A (retinol),tretinoin,placenta,hyaluronic acid,collagen,astaxanthin,xanthophyll,lycopene,beta-carotene,procyanidins,collagen peptides,heparinoids,etc. 5.Individuals currently participating in other clinical trials,those who have participated in other clinical trials within the past three months,or those who may undergo any of the above-mentioned tests or procedures during this study period. 6.Individuals who have difficulty completing various questionnaires. 7.Individuals who are pregnant,planning to become pregnant,or breastfeeding. 8.Subjects who have experienced severe sunburn within the past month. 9.Subjects with keloid tendencies,photosensitivity,or taking photosensitizing medications (e.g., tetracycline). 10.Subjects who have received treatment for skin aging spots (including laser treatment) within the past three months. 11.Subjects receiving immunosuppressive therapy. 12.Subjects who are otherwise deemed unsuitable by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Color difference measurement: Change in L value Image verification: Downtime (number of days until redness/scabbing), Post-inflammatory hyperpigmentation (PIH) incidence rate Subjective skin condition | — |
Secondary
| Measure | Time frame |
|---|---|
| Image Verification: Visual Assessment Score Blood Test: NAD+ Blood Levels Subjective Assessment (Skindex 29) VAS (Pain/Discomfort After Laser Treatment, Patient Satisfaction, Skin Quality, Fatigue, Sleep, etc.) | — |
Countries
Japan
Contacts
Public ContactShuichi Fukumoto
Mitsubishi Corporation Life Sciences Limited New Product Development Group Nutrition Business Division
Outcome results
None listed