A Study of the Swallowing Reflex and Pressure Changes Induced by Esophageal Water Stimulation

Elicitation of the Swallowing Reflex by Esophageal Water Stimulation: An Evaluation Using High-Resolution Manometry - EWSR-HRM Study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000060201

Enrollment

100

Registered

2025-12-25

Start date

2026-01-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dysphagia

Interventions

Water is infused into the esophagus via a transnasally inserted catheter to elicit the swallowing reflex (swallowing activity). The occurrence of induced swallowing and pharyngo-esophageal pressure re

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Individuals who have received sufficient explanation of the study overview, objectives, procedures, and ethical considerations, and who have provided written informed consent. Individuals who meet one of the following criteria: Older healthy participants (n = 20). Inpatients or outpatients with dysphagia (n = 50).

Exclusion criteria

Exclusion criteria: Individuals with current or past esophageal diseases, including gastroesophageal reflux disease (GERD). Individuals deemed inappropriate for participation in this study by the principal

Design outcomes

Primary

Measure	Time frame
Incidence of the swallowing reflex induced by esophageal stimulation, confirmed by high-resolution pharyngo-esophageal manometry	—

Countries

Japan

Contacts

Public ContactHIROSHIGE TANIGUCHI

Asahi University Department of Dysphagia Rehabilitation, Division of Oral Pathogenesis and Disease Control

h-taniguchi@dent.asahi-u.ac.jp0582538001

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026