Non-gonococcal Urethritis
Conditions
Interventions
Patients with non-gonococcal urethritis should receive minocycline 100 mg orally twice daily for 7 days. If testing at the start of minocycline therapy is positive for M. genitalium, sitafloxacin 100
Sponsors
Sapporo Medical University School of Medicine
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Symptoms: Patients presenting with symptoms of non-gonococcal urethritis. Pyuria: Cases meeting any of the following criteria for pyuria prior to initiation of medication. Using non-centrifuged urine with a designated device: >=10 WBCs/uL Using non-centrifuged urine with a urine test strip method (based on esterase activity measurement): Positive Urinalysis sediment microscopy: >=5 WBCs/hpf
Exclusion criteria
Exclusion criteria: 1) Patients who received other antimicrobial agents prior to study drug initiation and whose symptoms were already improving 2) Patients who received tetracycline-class antimicrobial agents within one week prior to study drug initiation 3) Patients with severe underlying diseases or complications that would make it difficult to evaluate the efficacy and safety of the study drug 4) Patients with a history of allergy to tetracycline-class antimicrobial agents 5) Patients with severe cardiac dysfunction or hepatic dysfunction 6) Patients with moderate or greater renal impairment (serum creatinine >= 2 mg/dL as a guideline) 7) Other patients deemed unsuitable by the attending physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy and Safety 21 to 28 Days After Initiation of Minocycline Treatment | — |
Countries
Japan
Contacts
Public ContactMitsuru Yasuda
Sapporo Medical University School of Medicine Department of Infection Control & Laboratory Medicine
Outcome results
None listed