Elucidation of Molecular Mechanisms Underlying Exercise-Induced Mood Improvement Using a Human Knockout Model

Elucidation of Molecular Mechanisms Underlying Exercise-Induced Mood Improvement Using a Human Knockout Model - Elucidation of Molecular Mechanisms Underlying Exercise-Induced Mood Improvement Using a Human Knockout Model

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000060156

Enrollment

Registered

2025-12-31

Start date

2026-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy adult men

Interventions

Participants will perform cycle ergometer exercise at 40% heart rate reserve for 30 minutes in the exercise condition, and maintain a resting state for 30 minutes in the control condition. Magnetic re

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Untrained individuals

Exclusion criteria

Exclusion criteria: Individuals with abnormal findings in medical check-ups. Individuals currently taking medication. Current smokers. Individuals unable to perform exercise at the prescribed intensity. Individuals with a history of vasovagal reflex (fainting) during blood sampling.

Design outcomes

Primary

Measure	Time frame
Plasma endocannabinoid concentrations (pre- and post-intervention)	—

Secondary

Measure	Time frame
Gene polymorphisms (CNR1, FAAH; baseline) Lifestyle habits (Food Frequency Questionnaire, Pittsburgh Sleep Quality Index, International Physical Activity Questionnaire; baseline) Heart rate (During intervention) Rating of Perceived Exertion (During intervention) Mood states (Physical Activity Affect Scale, Positive and Negative Affect Schedule; Pre- and post-intervention) mRNA expression levels (CB1R, FAAH; baseline) Activity levels (CB1R, FAAH; baseline)	—

Measure

Time frame

Gene polymorphisms (CNR1, FAAH; baseline) Lifestyle habits (Food Frequency Questionnaire, Pittsburgh Sleep Quality Index, International Physical Activity Questionnaire; baseline) Heart rate (During intervention) Rating of Perceived Exertion (During intervention) Mood states (Physical Activity Affect Scale, Positive and Negative Affect Schedule; Pre- and post-intervention) mRNA expression levels (CB1R, FAAH; baseline) Activity levels (CB1R, FAAH; baseline)

—

Countries

Japan,Europe

Contacts

Public ContactTETSUYA YABE

Yamanashi Gakuin University Faculty of Sport Science

yabe.tetsuya@c2c.ac.jp055-224-1377

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026