Impact of High-Density Lipoprotein Cholesterol Uptake Capacity on the Presence of Unstable Plaques in Culprit Lesions and Post-Procedural Outcomes in Patients Undergoing Percutaneous Coronary Intervention

Impact of High-Density Lipoprotein Cholesterol Uptake Capacity on the Presence of Unstable Plaques in Culprit Lesions and Post-Procedural Outcomes in Patients Undergoing Percutaneous Coronary Intervention - Impact of High-Density Lipoprotein Cholesterol Uptake Capacity on the Presence of Unstable Plaques in Culprit Lesions and Post-Procedural Outcomes in Patients Undergoing Percutaneous Coronary Intervention

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000060151

Enrollment

230

Registered

2025-12-22

Start date

2025-06-14

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary artery disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with coronary artery disease who underwent PCI with OCT at Kobe University Hospital between December 1, 2014, and August 31, 2022, and in whom CUC could be measured using stored frozen blood samples were included. Eligible patients were those who met all of the following inclusion criteria and none of the exclusion criteria. Inclusion criteria: 1. Patients with coronary artery disease who underwent PCI using OCT. 2. Patients from whom blood samples were collected during the hospitalization for PCI and in whom CUC could be measured using these samples. 3. Patients whose clinical information, including details of medical care, could be obtained from medical records. 4. Patients aged 20 years or older at the time of PCI.

Exclusion criteria

Exclusion criteria: 1. Patients who underwent PCI for in-stent restenosis or stent occlusion. 2. Patients receiving maintenance hemodialysis at the time of PCI. 3. Patients who underwent balloon dilation with a diameter greater than 2.0 mm or atherectomy using a rotablator before OCT imaging. 4. Patients in whom OCT analysis was considered difficult due to insufficient image quality. 5. Patients who requested not to participate in this study based on publicly disclosed information. 6. Any other patients deemed inappropriate for inclusion by the principal investigator.

Design outcomes

Primary

Measure	Time frame
Relationship between TCFA Prevalence and Cholesterol Uptake Capacity	—

Secondary

Measure	Time frame
Relationship between Post-PCI Major Cardiovascular Outcomes and Cholesterol Uptake Capacity	—

Countries

Japan

Contacts

Public ContactKotaro Higuchi

Kobe University Graduate School of Medicine Department of Cardiology

kh930108@gmail.com078-382-5111

Outcome results