Association between the Radial-Femoral Pressure Gradient and Perioperative Lactate Kinetics in Adult Cardiac Surgery: retrospective cohort study

Association between the Radial-Femoral Pressure Gradient and Perioperative Lactate Kinetics in Adult Cardiac Surgery: retrospective cohort study - RFPG-Lac study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000060128

Enrollment

500

Registered

2025-12-24

Start date

2025-12-24

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adult Cardiac Surgery

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients who underwent cardiac surgery using cardiopulmonary bypass under general anesthesia between September 2011 and October 2025 2) Placement of both radial and femoral arterial lines 3) Cases with the following time points and blood gas measurements recorded: ??(1) Arterial blood gas analysis (lactate and hemoglobin) obtained 0-60 minutes after completion of protamine administration ??(2) End-of-surgery time ??(3) ICU admission time ??(4) Arterial blood gas analysis (lactate) obtained 0-60 minutes after ICU admission 4) Patients aged 18 years or older

Exclusion criteria

Exclusion criteria: 1) Congenital heart disease surgery 2) Severe stenosis/occlusion, aneurysm, pseudoaneurysm, arteriovenous fistula, dissection, radiation- or inflammation-related lesions, or a history of vascular reconstruction (bypass, stent, or patch) involving the aorto-iliac-common femoral arterial segment 3) Use of mechanical circulatory support preoperatively, intraoperatively, or postoperatively (e.g., IABP, VAD, ECMO, Impella) 4) Severe hepatic dysfunction (Child-Pugh class C), maintenance dialysis, or intraoperative death 5) Failure to meet data-quality control criteria 6) Opt-out from the study

Design outcomes

Primary

Measure	Time frame
Lactate and Lactate Clearance at ICU Admission	—

Secondary

Measure	Time frame
Duration of mechanical ventilation (hours), prolonged mechanical ventilation >48 hours, VFD 28 (number of days without mechanical ventilation up to 28 days post-surgery), ICU length of stay, ICUFD 28 (number of days not in the ICU up to 28 days post-surgery), in-hospital mortality	—

Countries

Japan

Contacts

Public ContactTerumasa Matsuo

Shimane University Hospital Anesthesiology

tmatsuo@med.shimane-u.ac.jp0853202295

Outcome results