Drug-resistant focal epilepsy
Conditions
Interventions
During awake craniotomy, electrical cortical or intraparenchymal stimulation is performed to provoke seizures or seizure-like activities. Stimulation is delivered using a cortical mapping stimulator
Sponsors
Fujita Health University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with drug-resistant focal-onset epilepsy Patients deemed eligible for awake craniotomy based on preoperative evaluation and EEG conference Patients undergoing electrical stimulation during awake surgery for epileptogenic zone identification Or patients who previously underwent awake craniotomy for brain tumor resection in whom seizures were incidentally provoked by cortical stimulation
Exclusion criteria
Exclusion criteria: Patients considered unsuitable for safe awake surgery due to cognitive, psychiatric, or general medical conditions Patients in whom responses to intraoperative electrical stimulation are expected to be unrecordable or unevaluable Patients who do not provide informed consent (by the patient or proxy)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concordance between symptomatogenic zones identified by seizure symptoms and electroencephalographic findings induced by cortical electrical stimulation during awake surgery, and the final epileptogenic zone. | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative seizure outcome at 1 year Occurrence of serious adverse events related to intraoperative electrical stimulation | — |
Countries
Japan
Contacts
Public ContactMasanobu Kumon
Fujita Health University Department of Neurosurgery, School of Medicine
Outcome results
None listed