A Comprehensive Study on the Link Between Breathing Sensations, Emotions, and Pain, and Their Brain Mechanisms

A Multimodal Investigation into the Neural Mechanisms Linking Respiratory Interoception with Emotional and Pain Perception - Elucidating the Neural Basis of the Relationship Between Respiratory Interoception, Emotion, and Pain

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000060086

Enrollment

120

Registered

2025-12-16

Start date

2025-12-16

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic pain, affective disorder

Interventions

transcranial electrical stimulation: real, washout 1 week, sham transcranial electrical stimulation: sham, washout 1 week, real

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Individuals aged 18 years or older who voluntarily expressed willingness to participate after receiving an explanation of the study.

Exclusion criteria

Exclusion criteria: Presence of a cardiac pacemaker; implantation of a metal plate near the stimulation site; a history of neurological disorders (including peripheral or central nervous system disorders) or respiratory diseases; current use of medications that affect brain function; and consumption of alcohol, caffeine, or tobacco within 24 hours prior to the experiment.

Design outcomes

Primary

Measure	Time frame
Assessment of Respiratory Interoception: Task Accuracy and Subjective Evaluations	—

Secondary

Measure	Time frame
Neural activity data: EEG, MRI Assessment of pain perception: Heat and cold pain thresholds, heat and cold pain tolerance thresholds Emotion-related questionnaires: Pain-related measures (PCS, PVAQ, TSK), depression (BDI), anxiety (STAI), alexithymia (TAS), interoception (MAIA, IAS-J, IATS-J)	—

Countries

Japan

Contacts

Public ContactKoshi Iimuro

Niigata University of Health and Welfare Institute for Human Movement and Medical Sciences

hwd25001@nuhw.ac.jp025-257-4448

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026