Mental disorders and healthy control
Conditions
Interventions
None listed
Sponsors
Keio University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Participants aged 20 years or older (both depressed and healthy) from the existing dataset, "Longitudinal MRI study to elucidate neural circuit mechanisms associated with remission and recovery in mood disorders (commonly known as the L/R study)."
Exclusion criteria
Exclusion criteria: This study is an analytical study using an existing dataset, and will exclude 1. cases with insufficient medical information 2. cases who have expressed their intention not to participate through the opt-out process described below
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Endpoints (and their measures/evaluation methods): Evaluate the diagnostic performance for depression in the L/R study and assess differences in treatment efficacy among standard therapies (pharmacotherapy, CBT, ECT, rTMS) for each depression subtype. Regarding diagnostic performance for depression, diagnostic indices will be calculated using pre-existing programs applied to data from depressed patients and healthy controls. Diagnostic performance will be evaluated using indices such as AUC of the ROC curve, sensitivity, specificity, and discrimination rate based on the diagnostic indices for both groups. For depression subtypes, pre-existing programs will also be used to classify depression patient data into subtypes. Subsequently, longitudinal treatment data will be used to evaluate treatment responsiveness for each subtype. Secondary evaluation items (and their metrics/evaluation methods): Since the characteristics of groups receiving each treatment intervention may differ, we will evaluate diagnostic metric values and subtype classification rates among standard treatments (pharmacotherapy, CBT, ECT, rTMS) in the L/R study. For the depression group, we will calculate diagnostic indicators and subtypes using the pre-established program. Comparing these across standard treatments (pharmacotherapy, CBT, ECT, rTMS) will clarify the characteristics of each group. Exploratory evaluation items (and their indicators/evaluation methods): We will explore the relationship between depression diagnostic indicators and depression subtypes, as well as the relationship between depression diagnostic indicators/subtypes and clinical characteristics. | — |
Countries
Japan
Contacts
Public ContactJinichi Hirano
Keio University School of Medicine
Outcome results
None listed