A Comparative Application Study of Human Umbilical Cord-Derived Mesenchymal Stem Cell Conditioned Medium on Skin Dryness and Skin Sensitivity

A Single-Blind, Parallel-Group Interventional Study on the Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cell Conditioned Medium on Skin Dryness and Skin Sensitivity - A Single-Blind, Parallel-Group Interventional Study of Human Umbilical Cord-Derived Mesenchymal Stem Cell Conditioned Medium Applied to the Skin of Healthy Volunteers

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000060059

Enrollment

Registered

2025-12-15

Start date

2025-12-18

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Xerosis and Sensitive Skin

Interventions

Application of 0% human umbilical cord-derived mesenchymal stem cell conditioned medium (vehicle only) to the facial skin twice daily after face washing for 3 months. Application of 10% human umbilica

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Healthy females aged between 30 and 59 years 2. Individuals who have never experienced severe sensitive skin or allergic reactions to cosmetics in the past. 3. Individuals who do not have any chronic inflammatory skin diseases. 4. Individuals who, after receiving a sufficient explanation of the study, have fully understood the contents and have provided written informed consent of their own free will.

Exclusion criteria

Exclusion criteria: 1. Individuals who do not meet the inclusion criteria 2. Individuals whom the principal investigator judges to be inappropriate for participation in this study

Design outcomes

Primary

Measure	Time frame
The primary outcome measures are transepidermal water loss (TEWL) and stratum corneum hydration of the facial skin.	—

Secondary

Measure	Time frame
The secondary outcome measures are as follows: (1) Pruritus and skin irritation (e.g., stinging and burning sensations), assessed using a Numerical Rating Scale (NRS). (2) Wrinkle severity (3) Skin color (lightness and erythema) (4) Skin elasticity (5) Skin permeability (6) Dermatological findings (presence or absence of eruptions, erythema, and edema), evaluated by a dermatologist.	—

Countries

Japan

Contacts

Public ContactMitsukoshi Tominaga

Juntendo University Graduate School of Medicine Institute for Environmental and Gender-Specific Medicine

tominaga@juntendo.ac.jp047-353-3171

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026