Healthy male volunteers
Conditions
Interventions
During the 4-week intervention period, participants consume 70 mL of a beetroot beverage daily, and after a washout period, a second intervention is conducted in which they consume a placebo beverage.
Sponsors
Hokkaido University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Age 18-30 years Healthy volunteers who does no need regular medical visits Those who has no objection to the taste of the beetroot juice and can participate in this study for about 13 months (Two 4-week intervention periods separated by a 10-month washout period) Those who be able to give written informed consent to participate in this study
Exclusion criteria
Exclusion criteria: Individuals with extremely irregular sleep or dietary habits Individuals who engage in running, or equivalent exercise, for >3 hours per day on >6 days per week Individuals with a BMI >30, or systolic blood pressure >140 mmHg, or diastolic blood pressure >90 mmHg Individuals with local perfusion disorders (occlusive vascular disease) caused by organic stenosis or obstruction of arteries or veins Individuals with lymphedema of the upper arm Individuals undergoing hemodialysis Individuals who habitually consume foods or beverages containing red beet Individuals who cannot agree to consume the study beverage after waking and before gargling or brushing teeth Individuals who have received, or are scheduled to receive, antibiotics within three months prior to obtaining consent Other individuals deemed unsuitable as study participants by the principal investigator or co-investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison between conditions of changes in supraclavicular-chest skin temperature gradient during mild whole-body cold exposure before and after long-term intake of beetroot versus placebo beverage | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison between conditions of changes in skin blood flow during the hand cold immersion test before and after long-term intake of beetroot versus placebo beverages | — |
Countries
Japan
Contacts
Public ContactHitoshi Wakabayashi
Hokkaido University Faculty of Engineering
Outcome results
None listed