A Prospective Study on Autonomic Function, Ocular Circulation, Optic Nerve Damage, and Long-Term CPAP Effects in Glaucoma Patients With Obstructive Sleep Apnea

OSA in Glaucoma: Autonomic Dysfunction, Ocular Blood Flow, and CPAP Impact - Pathophysiologic Mechanisms Linking OSA and Glaucoma

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000059977

Enrollment

150

Registered

2026-01-19

Start date

2026-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

glaucoma patients with sleep apnea syndrome

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age between 20 and 85 years. 2. Diagnosis of primary open-angle glaucoma (POAG) or normal-tension glaucoma (NTG) with well-controlled intraocular pressure. 3.Diagnosis of sleep apnea syndrome (SAS) based on PSG derived AHI. 4. For the CPAP longitudinal study: AHI more than 20 and judged to require CPAP therapy. 5. Ability to perform reliable visual field testing. 6. Provision of written informed consent.

Exclusion criteria

Exclusion criteria: 1. Presence of arrhythmias or implanted pacemakers that interfere with HRV analysis. 2. Severe retinopathy, optic neuritis, or other optic nerve disorders not related to glaucoma. 3. Planned ophthalmic surgery during the observation period. 4. Presence of autoimmune diseases, hyperthyroidism, or other hormonal disorders. 5. Use of oral contraceptive pills. 6. Pregnant or planning to become pregnant or breastfeed during the study period. 7. Shift workers or individuals with irregular circadian rhythms. 8. Cases deemed inappropriate for participation by the principal investigator.

Design outcomes

Primary

Measure	Time frame
1, Changes in HRV parameters 2, Changes in LSFG measurements. 3, Progression slopes of visual field MD and visual field sensitivity. 4, Comparison of the above changes between patients with good CPAP adherence (more than 4 h/night, more than 80%) and those with poor adherence.	—

Countries

Japan

Contacts

Public ContactNORIKO HIMORI

TOHOKU UNIVERSITY Ophthalmology

noriko.himori.b3@tohoku.ac.jp0227177294

Outcome results