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Effectiveness of Whole Blood Transfusion in Adult Patients with Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Effectiveness of Whole Blood Transfusion in Adult Patients with Traumatic Brain Injury: A Systematic Review and Meta-Analysis - Effectiveness of Whole Blood Transfusion in Adult Patients with Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Status
Active, not recruiting
Phases
Unknown
Study type
Unknown
Source
JPRN
Registry ID
JPRN-UMIN000059948
Enrollment
Unknown
Registered
2025-12-08
Start date
2025-12-02
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

traumatic brain injury

Interventions

None listed

Sponsors

National Defense Medical College
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients aged 16 years or older with traumatic brain injury will be included. A comprehensive literature search will be conducted to capture a wide range of relevant studies. The characteristics of the retrieved studies will then be examined to ensure clinical and methodological consistency across patient populations, after which eligible studies will be selected for inclusion in the meta-analysis. Studies that do not meet the eligibility criteria but are considered relevant will be summarized narratively.

Exclusion criteria

Exclusion criteria: 1. Studies not involving human subjects 2. Pediatric cases (patients younger than 16 years) 3. Subgroup analyses in which no traumatic brain injury cases are included 4. Single-arm studies, case reports, conference abstracts, or protocol-only publications 5. Articles not written in English

Design outcomes

Primary

MeasureTime frame
mortality

Secondary

MeasureTime frame
1. Total transfusion volume (red blood cells, fresh frozen plasma, and platelet concentrates) 2. Complications: thrombosis (pulmonary embolism, deep vein thrombosis), acute kidney injury, pulmonary edema, acute respiratory distress syndrome, and infection

Countries

Japan

Contacts

Public ContactTatsunori Nagamura

National Defense Medical College Traumatology and Critical Care Medicine

tnaga0802@ndmc.ac.jp81-4-2995-1511

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Sep 19, 2026