Patients scheduled for cardiovascular surgery
Conditions
Interventions
Activated-astrocyte PET imaging ([18F]SMBT-1-PET)
Sponsors
National Center for Geriatrics and Gerontology
National Cerebral and Cardiovascular Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Individuals who have provided written informed consent for participation in the study. 2. Men and women aged 18 years or older at the time of consent. 3. Individuals scheduled to undergo cardiovascular surgery. 4. Individuals with no history of neurological disorders that could affect the study assessments. 5. Individuals who agree to the storage of biological samples in the NCVC Biobank.
Exclusion criteria
Exclusion criteria: 1. Individuals judged by the principal investigator or study physicians to be at a higher-than-usual risk of health injury due to participation in this study. 2. Individuals deemed unable to undergo the study examinations. 3. Individuals with severe comorbidities, or a history of such conditions, for whom the principal investigator or study physicians consider participation inappropriate. 4. Individuals with a history of psychiatric disorders, such as dementia or depression. 5. Individuals who are unable to remain still during examinations (applicable only when PET imaging is performed). 6. Individuals with a history of drug allergy (applicable only when PET imaging is performed). 7. Pregnant or possibly pregnant women, and breastfeeding women (applicable only when PET imaging is performed). 8. Individuals taking reversible or irreversible monoamine oxidase (MAO) inhibitors (applicable only when PET imaging is performed). 9. Individuals who smoke (applicable only when PET imaging is performed). 10. Any other individuals deemed unsuitable for participation by the principal investigator or study physicians.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the severity of delirium in patients scheduled for cardiovascular surgery and to clarify its association with blood biomarkers reflecting neuroinflammation and immune function. | — |
Secondary
| Measure | Time frame |
|---|---|
| To elucidate the relationship between activated-astrocyte PET imaging and blood biomarkers reflecting neuroinflammation and immune function. To elucidate the association between regional astrocyte activation and the onset and severity of delirium. | — |
Countries
Japan
Contacts
Public ContactYasuyuki Kimura
National Center for Geriatrics and Gerontology Department of Clinical and Experimental Neuroimaging
Outcome results
None listed