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The effect of endurance training on BMP4 as a mediator of Cardio-Ankle Vascular Index in women with type 2 diabetes with peripheral neuropathy: A randomized controlled trial

The effect of endurance training on BMP4 as a mediator of Cardio-Ankle Vascular Index in women with type 2 diabetes with peripheral neuropathy: A randomized controlled trial - effect of endurance training on BMP4 and arterial stiffness in type 2 diabetes

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000059908
Enrollment
38
Registered
2025-11-28
Start date
2025-12-20
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

women diabetic type2

Interventions

The intervention group will undergo 12 weeks of supervised aerobic endurance training (3 sessions/week, 60-75 min/session) on treadmills. Session structure will consist of: 1) warm-up (10 min brisk wa
weeks 3-6: 30-35 min
weeks 7-10: 35-40 min
weeks 11-12: 45 min). 3) intensity of 50-70% heart rate reserve (Karvonen formula) progressively increasing from 50-55% (weeks 1-4) to 60-65% (weeks 5-8) and then to 70% (weeks 9-12). 4) cool-down (5-

Sponsors

Shahrood University Of Technology
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Inclusion criteria will be: postmenopausal status (>=12 months amenorrhea), T2DM diagnosed according to ADA criteria with stable HbA1c (7.0-9.0% for >=12 months), fasting plasma glucose >126 mg/dL, MNSI score >7, BMI 25-39.9 kg/m^2, sedentary lifestyle (<1 structured exercise session/week).

Exclusion criteria

Exclusion criteria: Exclusion criteria will be: insulin therapy, uncontrolled hypertension (>=180/110 mmHg), cardiovascular event or revascularization in the past 12 months, active diabetic foot ulcer or Charcot arthropathy, severe neuropathy impairing safe exercise (MNSI >=10 or inability to walk 1.6 km), renal impairment (eGFR <45 mL/min/1.73 m^2), smoking, malignancy, thyroid disease or inflammatory disorders, and participation in a regular exercise or weight-loss program.

Design outcomes

Primary

MeasureTime frame
BMP-4.(pree test and post test) CAVI.(pree test and post test)

Countries

Asia(except Japan)

Contacts

Public Contactadel donyaei

Shahrood University Of Technology Physical Education and Sport Sciences

adelldonyai@yahoo.com098-2332395900

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Sep 19, 2026