age-related cataract
Conditions
Interventions
Standard phacoemulsification cataract surgery using established nucleus disassembly techniques, including phaco-chop and/or prechop techniques. Machine settings, ophthalmic viscosurgical devices, and
Sponsors
Sato Eye Clinic
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients aged 50 years or older with age-related cataract. Lens nucleus hardness graded II to IV according to the Emery-Little classification. Preoperative corneal endothelial cell density >= 1800 cells/mm2, with reliable and reproducible specular microscopy measurements. Ability to comply with all scheduled pre- and postoperative examinations, including visual acuity, corneal endothelial cell density, and anterior chamber flare measurements. Absence of any ocular or systemic conditions that may interfere with the evaluation of surgical outcomes. Written informed consent obtained after receiving a full explanation of the study procedures, risks, and benefits.
Exclusion criteria
Exclusion criteria: Eyes with traumatic, congenital, or secondary cataracts other than age-related cataracts Eyes with corneal diseases such as corneal degeneration, corneal dystrophy, corneal opacity, or Fuchs endothelial corneal dystrophy Preoperative corneal endothelial cell density < 1800 cells/mm2 or unreliable measurements History of intraocular surgery or ocular laser procedures (e.g., LASIK, PRK, SLT, glaucoma surgery) in the study eye Severe amblyopia, active ocular inflammation, or ocular surface disorders (e.g., severe dry eye) that may interfere with postoperative evaluation Eyes with coexisting ocular diseases such as glaucoma, diabetic retinopathy, or significant macular diseases (AMD, macular hole, epiretinal membrane, etc.) Eyes requiring combined surgery other than intraocular lens implantation (e.g., glaucoma surgery, vitrectomy) Eyes or patients with uncontrolled intraocular pressure, optic nerve disorders, or systemic conditions that substantially increase surgical risk Patients unable to comply with the scheduled examinations or follow-up visits
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change rate in corneal endothelial cell density (change rate at 19 weeks post-surgery relative to pre-surgery) *Long-term follow-up evaluations at 52 weeks, 104 weeks, etc., may be added in the future. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. CDE (Cumulative Dissipated Energy) 2. Effective Ultrasound Time (EPT) 3. Irrigation Fluid Volume 4. Suction time 5. Intraoperative complications 6. Postoperative anterior chamber flare value 7. Corneal thickness changes 8. Visual acuity (BCVA) 9. Correlation between intraoperative fluid settings (IOP, flow, vacuum) and ECL% 10. Subgroup analysis by nucleus hardness and surgical technique 11. Endothelial cell loss rate in long-term follow-up (up to 5 years) | — |
Countries
Japan
Contacts
Public ContactTsuyoshi Sato
Sato Eye Clinic Director
Outcome results
None listed