(1) Age: Participants aged 30 to 64 years at the time of registration. (2) Sex: Both males and females are eligible. (3) Water Intake Requirement: Individuals who are able to consume 1 liter of natural reduced water or tap water daily throughout the 6-month study period. (4) Informed Consent: Individuals who are capable of providing written informed consent to participate in the study. (5) Stress Questionnaire: Individuals who have completed the stress-related questionnaire(s) requir
Conditions
Interventions
Sponsors
Tohoku University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Age: Participants aged 30 to 64 years at the time of registration. (2) Sex: Both males and females are eligible. (3) Water Intake Requirement: Individuals who are able to consume 1 liter of natural reduced water or tap water daily throughout the 6-month study period. (4) Informed Consent: Individuals who are capable of providing written informed consent to participate in the study. (5) Stress Questionnaire: Individuals who have completed the stress-related questionnaire(s) required for the study.
Exclusion criteria
Exclusion criteria: Participants who meet any of the following conditions at the time of registration will be excluded from this study. Individuals with severe diseases, underlying conditions related to electrolyte abnormalities such as hyponatremia, or those taking medications that may cause such abnormalities will be excluded. (1) Individuals who are unable to provide informed consent. (2) Individuals with a history of dementia or neurological disorders. (3) Individuals receiving medical treatment for any of the following chronic diseases: - Renal diseases - Cardiovascular diseases - Liver cirrhosis - SIADH (Syndrome of Inappropriate Antidiuretic Hormone Secretion) - Hypothyroidism - Diabetes mellitus or hyperlipidemia - Psychiatric disorders (including polydipsia associated with psychiatric conditions) - Persistent vomiting or diarrhea - Autoimmune or immunological diseases - Electrolyte abnormalities (4) Individuals taking any of the following medications: - Antiepileptic drugs - Antidepressants - Diuretics - Antihypertensive agents - Antiarrhythmic drugs (5) Individuals with severe visual or hearing impairments. (6) Individuals who have consumed natural reduced water continuously within the past two years. (7) Pregnant or breastfeeding women. (8) Individuals currently participating in another clinical study. (9) Individuals for whom participation in the study is deemed difficult by the investigators. (10) Individuals who belong to the department(s) of the principal investigator or co-investigators (including affiliated or joint-appointment departments), such as students, graduate students, and staff. (11) Individuals with a Body Mass Index (BMI) of less than 18.5kg/m^2.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Scores of stress-related questionnaires Blood levels of stress-related proteins | — |
Countries
Japan
Contacts
Public ContactKeishi Soga
Tohoku University Smart Aging Research Center
Outcome results
None listed