Chronic kidney disease and cardiovascular-kidney-metabolic syndrome
Conditions
Interventions
None listed
Sponsors
the University of Tokyo
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Participants in this study shall be individuals who meet all of the following criteria: Aged 18 years or older No restriction on sex Meeting at least one of the following conditions: Studies using kidney specimens: Patients who, on or after January 1, 2020, required renal biopsy or living-donor kidney transplantation as part of routine clinical care, or who have already undergone renal biopsy or living-donor kidney transplantation. In cases of living-donor kidney transplantation, donors will also be included. Studies using vascular specimens: Patients who, on or after January 1, 2020, required arteriovenous fistula creation or synthetic vascular graft implantation as part of routine clinical care, or who have already undergone these procedures. Studies using plasma specimens: Patients who are enrolled in the J-Kidney-Biobank and whose plasma samples have been banked in the biobank.
Exclusion criteria
Exclusion criteria: Individuals meeting any of the following conditions will not be included in this study: Cases in which the investigator determines that participation is undesirable, such as when there is a risk of compromising data reliability. Cases involving kidney transplantation performed using deceased donors rather than living donors. Individuals who have expressed refusal for their information to be used in this study. Individuals who lack the capacity to provide informed consent. Cases in which no specimens are available for analysis, for example, when no residual samples remain beyond those required for routine clinical care.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| As this study is exploratory in nature, no specific primary endpoint will be defined. However, to achieve the study objectives, the following items will be designated as the main analytical focus. Main analytical focus is as follows: Identification of cell populations and analysis of disease-associated pathways in kidney tissue using single-cell and spatial transcriptomic analysis, identification of disease-associated cells in vascular tissue using single-cell transcriptomic analysis, exploration of CKM syndrome-related biomarkers through plasma proteomic analysis. | — |
Countries
Japan
Contacts
Public ContactYuka Sugawara
the University of Tokyo Hospital Division of Nephrology and Endocrinology
Outcome results
None listed