Maintenance of antidepressant effect by magnetic modulation (rTMS) among patients with treatment-resistant depression who responded to low dose ketamine infusion: a double-blind randomized sham rTMS-controlled study

Maintenance of antidepressant effect by magnetic modulation (rTMS) among patients with treatment-resistant depression who responded to low dose ketamine infusion: a double-blind randomized sham rTMS-controlled study - ketamine+rTMS study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000059848

Enrollment

Registered

2026-06-01

Start date

2024-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Treatment-resistant depression (TRD)

Interventions

Ketamine 0.5mg+rTMS Ketamine 0.5mg+sham rTMS

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Major depressive episode including unipolar and bipolar depression, according to DSM-5 criteria and MINI (Mini International Neuropsychiatric Interview;MINI) diagnostic interview

Exclusion criteria

Exclusion criteria: 1)Major medical conditions e.g.:head injury, epilepsy, severe renal diseases and cancer. 2)Other axis I psychiatric disorders such as schizophrenia, delusional disorder, organic brain syndrome, and dementia. 3)Pregnancy and Breastfeeding women 4)Substance abuse in previous 6 months such as cocaine, marijuana, opium, ketamine, PCP phencyclidine. 5)Current use of NMDA receptor antagonist Amantadine, Rimantadine, Lamotrigine,Memantine, Dextromethorphan 6)Alcohol abuse and dependence within 6 months. 7)Allergy to Ketamine and Rapamycin. 8)Implanted cardiac pacemaker within 30 cm or metal material like vessel clip in the brain. 9)Those are unable to express willingness to participate.

Design outcomes

Primary

Measure	Time frame
MRI,MADRS,HAMD	—

Countries

Asia(except Japan)

Contacts

Public ContactTung-Ping Su

Cheng-Hsin General Hospital Department of Psychiatry

tomsu0402@gmail.com+886-928593009

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026