Hepatic cirrhosis
Conditions
Interventions
A nutritional intervention with a guideline-based high-protein diet will be conducted in patients with liver cirrhosis using an AI-based dietary application. After a 3-month intervention period, a 3-m
Sponsors
Japan Institute for Healthy Security
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Individuals who have provided written informed consent to participate in the study 2. Males or females aged >=20 and <100 years at the time of consent 3. Individuals clinically diagnosed with liver cirrhosis 4. Individuals with serum albumin level <=4.0 g/dL
Exclusion criteria
Exclusion criteria: 1. Individuals with a history of congenital amino acid metabolism disorders 2. Individuals currently taking amino acid preparations 3. Individuals who initiated or changed the dose of diuretics, synthetic disaccharides, or rifaximin within the past 6 months 4. Individuals who are pregnant or breastfeeding 5. Individuals currently undergoing treatment for malignancies other than hepatocellular carcinoma 6. Individuals with difficulty in oral intake 7. Individuals with disorders affecting digestion or absorption 8. Individuals with impaired renal function (eGFR < 60 mL/min/1.73 m2) 9. Individuals deemed unsuitable for study participation by the principal investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in amino acid intake between the improvement and non-improvement groups based on liver cirrhosis-related blood tests, muscle strength, questionnaires, and hepatic encephalopathy tests (Stroop test) | — |
Countries
Japan
Contacts
Public ContactEiji Kakazu
National Kohnodai Medical Center, Japan Institute for Healthy Security Department of Gastroenterology and Hepatology
Outcome results
None listed