Chronic bronchitis, Bronchiectasis, Non-tuberculous mycobacterial pulmonary disease, Chronic lower airway infection, COPD with chronic sputum symptoms, COPD (chronic obstructive pulmonary disease)
Conditions
Interventions
None listed
Sponsors
Hirotoshi Yasui, M.D. Department of Respiratory Medicine Toyohashi Municipal Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Participants must meet all of the following: Adults (>=18 years) Diagnosed with chronic lower airway disease, including: Chronic bronchitis, Bronchiectasis, Non-tuberculous mycobacterial lung disease, COPD with sputum symptoms Scheduled to start OPEP as part of routine clinical care CAT score >=10 OR CAT 7-9 with sputum item score >=3 Able to provide written informed consent Baseline assessments available within protocol-defined time windows
Exclusion criteria
Exclusion criteria: Acute exacerbation within the past 4 weeks Severe cardiac or cognitive conditions that preclude valid evaluation Contraindications to safe OPEP use (e.g., current pneumothorax) Withdrawal of consent before data lock Inability to ensure clinical stability at the evaluation timepoint
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in CAT score at 12 weeks after initiation of OPEP therapy | — |
Secondary
| Measure | Time frame |
|---|---|
| CAT responder rate (>= 2-point improvement), Change in CT mucus plug score, Change in %FEV1, Exploratory analysis of predictors of response | — |
Countries
Japan
Contacts
Public ContactHirotoshi Yasui
Toyohashi Municipal Hospital Department of Respiratory Medicine
Outcome results
None listed