Healthy middle-aged men and women
Conditions
Interventions
Exercise intervention
Control
Sponsors
Tohoku University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Men and women aged 40 to 55 years 2. Individuals who are able to participate in a three-month exercise program (three sessions per week) during the study period 3. Individuals with a BMI of 18.5-30.0 kg/m^2 4. Individuals who are able to attend the exercise program three times per week for three months during the study period 5. Individuals who provide written informed consent to participate in the study
Exclusion criteria
Exclusion criteria: (1) Individuals who are unable to provide informed consent (2) Individuals who are prohibited from engaging in exercise (3) Individuals who are currently participating in another clinical study (4) Individuals deemed otherwise unsuitable for study participation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DNA methylation-based aging clocks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Blood biomarkers 1 (GMM, MME, DMP, DMR, etc.) 2. Blood biomarkers 2 (transcriptome, T cell-derived aging biomarkers, metabolome, plasma copeptin, plasma osmolality, plasma sodium) 3. Gut microbiota (shotgun metagenomics) 4. Morphological parameters (height, body weight, body composition, waist circumference, calf circumference) 5. Physical fitness parameters (Chester step test, handgrip strength, vertical jump) 6. Cognitive function (TMT-A/B, Stroop task, Flanker task, n-back task) 7. Psychological function (WHO QOL-26, POMS2, PSS, K10) 8. Lifestyle factors (PSQI, BDHQ, MEQ, self-administered questionnaire) 9. Urinary indices (urine specific gravity, urine osmolality) | — |
Countries
Japan
Contacts
Public ContactTakuji Kawamura
Tohoku University Smart-Aging Research Center
Outcome results
None listed