Diagnostic Accuracy of the Bowel Wall Flow Assessed by MV-Flow in Detecting Inflammation Severity in Ulcerative Colitis: A Comparative Study with Endoscopic Severity (FLOW Trial)

Diagnostic Accuracy of the Bowel Wall Flow Assessed by MV-Flow in Detecting Inflammation Severity in Ulcerative Colitis: A Comparative Study with Endoscopic Severity (FLOW Trial) - Diagnostic Accuracy of the Bowel Wall Flow Assessed by MV-Flow in Detecting Inflammation Severity in Ulcerative Colitis: A Comparative Study with Endoscopic Severity (FLOW Trial)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000059711

Enrollment

Registered

2025-11-10

Start date

2024-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ulcerative colitis

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Consecutive patients more than 15 years old who have a UC undergoing endoscopy for evaluation of disease activity or surveillance were eligible for inclusion.

Exclusion criteria

Exclusion criteria: If there was a change in treatment or symptoms between IUS and endoscopy, patients were excluded. Patients with a history of total colectomy and pregnant women were also excluded.

Design outcomes

Primary

Measure	Time frame
The aim of this study is to create a validated scoring system using MV-Flow to assess the endoscopic severity in patients with UC. This involves the creation of a scoring system based on the localization and shape of blood flow signals in the mucosa, submucosa, and muscularis propria, as well as the assessment of the proportion of blood vessels within the wall (using vascularity indices, which were the ratio (%) of color pixels in the total grayscale pixels in a defined region of interest) and the degree of blood flow using a VAS scale.	—

Measure

Time frame

The aim of this study is to create a validated scoring system using MV-Flow to assess the endoscopic severity in patients with UC. This involves the creation of a scoring system based on the localization and shape of blood flow signals in the mucosa, submucosa, and muscularis propria, as well as the assessment of the proportion of blood vessels within the wall (using vascularity indices, which were the ratio (%) of color pixels in the total grayscale pixels in a defined region of interest) and the degree of blood flow using a VAS scale.

—

Secondary

Measure	Time frame
Comparison of the Modified Limberg score with the assessment of inflammation evaluated by endoscopic and histological findings.	—

Countries

Japan

Contacts

Public ContactTaku Kobayashi

Kitasato University Kitasato Institute Hospital Center for Advanced Treatment of Inflammatory Bowel Disease

drkobataku@gmail.com0334446161

Outcome results