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Exploring a New Non-invasive Treatment for Motion Sickness Using Electrical Nerve Stimulation

A Pilot Study on Non-invasive Electrical Nerve Stimulation Therapy for Motion Sickness - A Pilot Study on Non-invasive Electrical Nerve Stimulation Therapy for Motion Sickness

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000059695
Enrollment
30
Registered
2025-11-10
Start date
2025-11-11
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Motion Sickness

Interventions

Under the TENS-off condition, rotational stimulation at 60 degrees/sec will be applied for one minute, followed by one minute of post-rotatory nystagmus recording. The intervention will be conducted o

Sponsors

St. Marianna University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Healthy adult men and women aged 18 years or older who have provided informed consent and do not meet any of the exclusion criteria.

Exclusion criteria

Exclusion criteria: Individuals with a history of vestibular dysfunction Individuals using a pacemaker Individuals with a history of severe motion sickness Individuals with skin conditions that make transcutaneous electrical nerve stimulation (TENS) difficult to apply Pregnant individuals

Design outcomes

Primary

MeasureTime frame
In this study, post-rotatory nystagmus will be recorded for one minute following a rotational stimulation at 60degrees/sec under both conditions: with and without TENS application. From the obtained slow phase eye velocity (SPEV), the time required for the SPEV to decay to 37% of the maximal value (MaxSPEV) will be calculated as the time constant. Vestibular responses with and without TENS will be compared. Statistical analysis will be performed using the Wilcoxon signed-rank test to evaluate differences between conditions.

Secondary

MeasureTime frame
The Motion Sickness Assessment Questionnaire (MSAQ) scores will be compared between the TENS and non-TENS conditions to evaluate subjective changes in motion sickness symptoms induced by TENS.

Countries

Japan

Contacts

Public ContactNayu Yokoyama

St. Marianna University School of Medicine Otolaryngology

nayu.yokoyama@marianna-u.ac.jp044-977-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026