Effects of Different Stimulation Intensities of Transcutaneous Auricular Vagus Nerve Stimulation on Changes in the Functional State of the Locus Coeruleus-Noradrenaline System During Cognitive Activity: A Single-Blind Randomized Controlled Trial

Effects of Different Stimulation Intensities of Transcutaneous Auricular Vagus Nerve Stimulation on Changes in the Functional State of the Locus Coeruleus-Noradrenaline System During Cognitive Activity: A Single-Blind Randomized Controlled Trial - Effects of Different Stimulation Intensities of Transcutaneous Auricular Vagus Nerve Stimulation on Changes in the Functional State of the Locus Coeruleus-Noradrenaline System During Cognitive Activity: A Single-Blind Randomized Controlled Trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000059680

Enrollment

Registered

2026-02-01

Start date

2026-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy adults

Interventions

Individually adjusted intensity transcutaneous auricular vagus nerve stimulation Transcutaneous auricular vagus nerve stimulation at 0.5mA intensity Non-irritating

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Native language is Japanese Right-handed

Exclusion criteria

Exclusion criteria: History of epileptic seizures or family history Presence of neurological, psychiatric, or cardiac disorders History of external ear trauma Presence of internal implants Regular use of medications Pregnancy Alcohol or drug dependence

Design outcomes

Primary

Measure	Time frame
Event-related potential	—

Countries

Japan

Contacts

Public ContactHiroki Annaka

Niigata University of Health and Welfare Department of Occupational Therapy

hiroki-annaka@nuhw.ac.jp025-257-4437

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026