A Randomized Controlled Trial Evaluating the Utility of Preserving the Posterior Pulmonary Nerve Plexus During Mediastinal Lymph Node Dissection for Esophageal Cancer

A Randomized Controlled Trial Evaluating the Utility of Preserving the Posterior Pulmonary Nerve Plexus During Mediastinal Lymph Node Dissection for Esophageal Cancer - A Randomized Controlled Trial Evaluating the Utility of Preserving the Posterior Pulmonary Nerve Plexus During Mediastinal Lymph Node Dissection for Esophageal Cancer

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000059630

Enrollment

Registered

2025-11-04

Start date

2026-05-20

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

esophageal cancer

Interventions

Preserve the Posterior Pulmonary Plexus of autonomic nerve Preserving group Not preserving the Posterior Pulmonary Plexus of autonomic nerve None preserving group

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who are planned to undergo esophagectomy with middle to lower esophageal cancer with clinical stage I-IVA Patients are older than 18 years old Performance status (PS) is 0 to 2 according to ECOG criteria Patients who consented with own free will to this study after receiving sufficient explanation and with adequate understanding

Exclusion criteria

Exclusion criteria: cases which tumor invaded to posterior pulmonary nerve plexus of autonomic nerve Cases that are currently cancer-bearing other than esophageal cancer Cases with severe respiratory disorders such as pulmonary emphysema, interstitial pneumonia, or bronchial asthma Cases with severe liver dysfunction, cirrhosis, or active hepatitis Cases with severe renal dysfunction Cases with poorly controlled diabetes Pregnant women or those who may be pregnant, women who are breastfeeding Cases diagnosed inappropriate to conduct this research safely by principal investigator

Design outcomes

Primary

Measure	Time frame
Incidence rate of postoperative chronic cough	—

Countries

Japan

Contacts

Public ContactTakuji Sato

Kansai Medical University Department of Upper Gastrointestinal Surgery

satou.tak@kmu.ac.jp072-804-0101

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026