Chronic Kidney Disease
Conditions
Interventions
The exercise intensity of Nordic Walking (NW) will be determined based on the exercise tolerance evaluated by a cardiopulmonary exercise test (CPX). In addition, the Rating of Perceived Exertion (RPE
Borg scale, range 6-20) will be used, and participants will be instructed to exercise at an intensity corresponding to a Borg score of 11-13 (somewhat hard).According to the CPX results, NW will be re
Sponsors
Tokyo University of Science
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients attending the outpatient clinic of the Department of Nephrology at the Japanese Red Cross Medical Center who meet the criterion of renal function with an estimated glomerular filtration rate (eGFR) between 7 and 20 mL/min/1.73 m2 will be included. The lower limit of renal function was determined with reference to the IDEAL study (Cooper BA et al, N Engl J Med 2010; 363:609-619).
Exclusion criteria
Exclusion criteria: 1 Patients contraindicated for exercise therapy (specifically the following): Uncontrolled hypertension (persistent systolic blood pressure >= 180 mmHg or diastolic blood pressure >= 110 mmHg) Severe anemia (Hb < 7 g/dL) Active proliferative diabetic retinopathy Individuals who developed symptomatic coronary artery disease or cerebrovascular disease within the past 3 months Uncontrolled heart failure (NYHA Class III or higher) Severe or life-threatening arrhythmias with significant symptoms Severe valvular heart disease Individuals with difficulty walking due to orthopedic conditions, cerebrovascular disease, peripheral arterial disease, etc. 2 Patients with unstable systemic conditions (specifically the following): Uncontrolled uremia (BUN > 100 mg/dL, K > 6.0 mEq/L, HCO3 < 18 mmol/L) 3 Other patients deemed unsuitable as subjects by the principal investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All patients attending the outpatient clinic of the Department of Nephrology, Japanese Red Cross Medical Center, with an eGFR between 7 and 20 mL/min/1.73 m2 who meet the inclusion criteria will be recruited. The exercise intervention period will last for 12 weeks from the baseline assessment, with follow-up evaluations conducted at 12 weeks. The primary endpoints will be the CPX parameters: peak VO2 (peak oxygen uptake), AT (anaerobic threshold), and VE vs VCO2 slope (ventilatory efficiency slope). | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome measures will include handgrip strength, appendicular skeletal muscle mass (measured using a body composition analyzer, Tanita MC-780MA-N, Tanita Corp., Tokyo, Japan), body composition (Tanita MC-780MA-N), chronic kidney disease (CKD)-related laboratory outcomes (Ca, P, intact PTH, TC, HDL, TG, Hb, Alb, HbA1c), and health-related quality of life (HR-QOL). | — |
Countries
Japan
Contacts
Public ContactSonoda Rena
Tokyo University of Science Department of Advanced Bioethics and Medical Science
Outcome results
None listed