Effects of Different Flow Rates in High-Flow Nasal Cannula Oxygen Therapy on Exercise Tolerance

Effects of Different Flow Rates in High-Flow Nasal Cannula Oxygen Therapy on Exercise Tolerance - The Effect of Different HFNC Flow Rates on Exercise Tolerance

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000059588

Enrollment

Registered

2025-11-01

Start date

2025-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy adults

Interventions

High-Flow Nasal Cannula Oxygen Therapy Settings: FiO2 0.21, Flow 30 L/min High-Flow Nasal Cannula Oxygen Therapy Settings: FiO2 0.21, Flow 45 L/min High-Flow Nasal Cannula Oxygen Therapy Settings: FiO

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Young healthy males who understood the purpose of this study and provided informed consent

Exclusion criteria

Exclusion criteria: Individuals for whom cardiopulmonary exercise testing is difficult due to musculoskeletal disorders or lower limb pain Individuals with a history of respiratory or cardiovascular disease Individuals who have smoked within the past month

Design outcomes

Primary

Measure	Time frame
Exercise duration	—

Secondary

Measure	Time frame
1. Subjective dyspnea and lower limb fatigue: Before nasal cannula placement, before CPX, after warm-up, and every minute after exercise initiation 2. Ease of exhalation and inhalation, nasal cannula discomfort (assessed using Visual Analog Scale): Before and after the experiment 3. Vital signs (SpO2, pulse rate, respiratory rate): Before nasal cannula placement, before CPX, after warm-up, every minute after exercise load initiation	—

Measure

Time frame

1. Subjective dyspnea and lower limb fatigue: Before nasal cannula placement, before CPX, after warm-up, and every minute after exercise initiation 2. Ease of exhalation and inhalation, nasal cannula discomfort (assessed using Visual Analog Scale): Before and after the experiment 3. Vital signs (SpO2, pulse rate, respiratory rate): Before nasal cannula placement, before CPX, after warm-up, every minute after exercise load initiation

—

Countries

Japan

Contacts

Public ContactYorihide Yanagita

Nagasaki University Graduate School of Biomedical Sciences

y-yanagita@nagasaki-u.ac.jp095-819-7967

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026