Liver metastases from pancreatic and gastrointestinal neuroendocrine tumors
Conditions
Interventions
None listed
Sponsors
Kyoto University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1 Histologically confirmed pancreatic or gastrointestinal neuroendocrine tumor 2 Presence of synchronous or metachronous liver metastases that are deemed unresectable for one or more of the following reasons, Functionally unresectable, Technically unresectable, Oncologically unresectable 3 Absence of extrahepatic metastases confirmed by somatostatin receptor imaging. 4 Availability of an appropriate living donor candidate. 5 Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. 6 Adequate function of major organs 7 Age between 18 and 69 years
Exclusion criteria
Exclusion criteria: 1. Histologically diagnosed neuroendocrine carcinoma or mixed neuroendocrine-non-neuroendocrine neoplasm. 2. Unknown primary site of the neuroendocrine tumor. 3. Presence of extrahepatic distant metastases. 4. Presence of active double cancers, concurrent malignancies requiring treatment. 5. Presence of active infections requiring treatment. 6. Pregnant or potentially pregnant women. 7. Presence of psychiatric disorders or symptoms that interfere with daily life and are considered to make participation in the study difficult. 8. Any other cases deemed ineligible for living donor liver transplantation under standard clinical practice.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall Survival | — |
Secondary
| Measure | Time frame |
|---|---|
| Disease-free survival, graft survival rate, postoperative complication rate, in-hospital mortality, and 90-day postoperative mortality | — |
Countries
Japan
Contacts
Public ContactKei Yamane
Graduate School of Medicine and Faculty of Medicine Kyoto University Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery
Outcome results
None listed