A Study on the Effects of Gargling with Alkaline Ionized Water on Salivary Levels of Caries-Causing Bacteria

Effects of Alkaline Ionized Water Gargling on Streptococcus mutans Levels and Salivary Properties - Alkaline Ionized Water - Streptococcus Mutans Study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000059490

Enrollment

Registered

2025-10-21

Start date

2018-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental caries

Interventions

Participants will gargle with alkaline ionized water three times daily, immediately after each meal (breakfast, lunch, and dinner), for a total of 30 consecutive days. Each gargling session will last

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Twenty functional teeth or more. Able to provide written informed consent.

Exclusion criteria

Exclusion criteria: Known allergy or hypersensitivity to any mineral components in alkaline ionized water. Medical conditions contraindicating gargling (e.g., dysphagia or severe oral dysfunction). Ongoing dental treatment for active caries or other oral diseases that may affect study assessments. Concurrent participation in other oral health programs or clinical studies that may influence the results of this study.

Design outcomes

Primary

Measure	Time frame
Change in salivary Streptococcus mutans levels before and after a 30-day gargling intervention with alkaline ionized water.	—

Countries

Japan

Contacts

Public ContactMegumi Suzuki

The Nippon Dental University College at Tokyo Department of Dental Hygiene

megumi-t@tandai.ndu.ac.jp+81-3-3266-5063

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026