The role of genetic polymorphisms in the effects of caffeine intake on cognitive function: based on CYP1A2 genotype

The Role of Genetic Polymorphisms in the Effects of Caffeine Intake on Cognitive Function: A Randomized Double-Blind Crossover Trial Based on CYP1A2 Genotype - Caffeine Intake and Cognitive Function: The Role of Genetic Factors (CYP1A2 Genotype)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000059479

Enrollment

Registered

2025-10-20

Start date

2025-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Following caffeine ingestion (6 mg/kg, administered in capsule form), the Psychomotor Vigilance Task (PVT) was initiated 25 minutes post-administration and consisted of seven repetitions of a 10-minut

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Healthy males aged 18 to 39 years

Exclusion criteria

Exclusion criteria: Individuals with a history of chronic diseases Individuals currently taking medication Individuals with unstable sleep patterns

Design outcomes

Primary

Measure	Time frame
The outcome measures in the Psychomotor Vigilance Task (PVT) include mean reaction time, the fastest and slowest 10% of reaction times, the number of lapses (reaction time > 500 ms), the number of false responses, and the variability of reaction times.	—

Secondary

Measure	Time frame
Subjective anxiety experienced by participants during the experiment	—

Countries

Japan

Contacts

Public ContactJinxingze Cheng

Waseda University Graduate School of Sport Sciences

teisinnseitaku@akane.waseda.jp08058049614

Outcome results