A Study on the Effect of the White Coat Effect on Adrenaline Induced Blood Pressure Elevation

A Cohort Study on the Effect of the White Coat Effect on Adrenaline-Induced Blood Pressure Elevation - A Study on the Effects of the White Coat Effect on Adrenergic Blood Pressure Elevation

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000059469

Enrollment

100

Registered

2025-10-21

Start date

2025-10-21

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Anesthesiology

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing dental treatment requiring local anesthesia

Exclusion criteria

Exclusion criteria: Severe cardiovascular disease (unstable angina, myocardial infarction within the past 6 months, severe heart failure (NYHA class III/IV), severe arrhythmia) Blood pressure-related disorders (secondary hypertension, severe hypertension ) Drug-related (Contraindications to epinephrine-containing lidocaine hydrochloride preparations, use of beta-blockers) Pharmacologically assisted behavioral modification (Psychotropic sedation, general anesthesia) Other (Pregnancy or lactation, contraindications to upper arm blood pressure measurement, difficulty cooperating due to dementia, psychiatric disorders, intellectual disability, etc. Deemed inappropriate by the principal investigator)

Design outcomes

Primary

Measure	Time frame
Blood pressure and pulse rate after local anesthesia: Measure and record blood pressure and pulse rate twice each immediately before, immediately after, 5 minutes after, 10 minutes after, and 30 minutes after the local anesthetic injection. Compare the change rate in systolic blood pressure between the white coat effect group and the control group. Furthermore, the primary endpoint was a multivariate linear regression analysis adjusted for age, sex, BMI, medical history, epinephrine dose, and treatment content.	—

Measure

Time frame

Blood pressure and pulse rate after local anesthesia: Measure and record blood pressure and pulse rate twice each immediately before, immediately after, 5 minutes after, 10 minutes after, and 30 minutes after the local anesthetic injection. Compare the change rate in systolic blood pressure between the white coat effect group and the control group. Furthermore, the primary endpoint was a multivariate linear regression analysis adjusted for age, sex, BMI, medical history, epinephrine dose, and treatment content.

—

Secondary

Measure	Time frame
Secondary endpoints include the change rate in diastolic blood pressure, change rate in mean arterial pressure, change rate in heart rate, and incidence rate of adverse events.	—

Countries

Japan

Contacts

Public ContactHidetaka Kuroda

Kanagawa Dental University Department of Anesthesiology, Division of Dental Anesthesiology

kuroda@kdu.ac.jp0468228751

Outcome results