The Clinical Features and Underlying Neural Mechanisms of Late-Life Depression

The Clinical Features and Underlying Neural Mechanisms of Late-Life Depression - CNLLD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000059466

Enrollment

200

Registered

2025-11-01

Start date

2023-03-28

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Late-Life Depression

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Individuals diagnosed with Major Depressive Disorder, either outpatients or inpatients in Keio University hospital. 2.Individuals 60 years of age or older at the time of informed consent. 3.Individuals who are clinically free of any overt neurodegenerative disorder at the time of informed consent. 4.Individuals who are capable of providing written informed consent for this study.

Exclusion criteria

Exclusion criteria: 1.Individuals with co-morbid disorders that are determined to be severe or significantly unstable. 2.Individuals with a history of head trauma or substance dependence. 3.Individuals with a pacemaker or other metallic implants. 4.Individuals with current or a history of epilepsy or generalized seizures. 5.Individuals judged as unsuitable for participation in this study by the investigators for any other reason.

Design outcomes

Primary

Measure	Time frame
Differentiations in cognitive function, biological response indicators and brain structure.	—

Countries

Japan

Contacts

Public ContactJinichi Hirano

Department of Neuropsychiatry School of Medicine

hjinichi@keio.jp03-3353-1211

Outcome results