A prospective cohort study on predictors of renal function decline in a population at risk for the onset and progression of chronic kidney disease

A prospective cohort study on predictors of renal function decline in a population at risk for the onset and progression of chronic kidney disease - A prospective cohort study on predictors of renal function decline in a population at risk for the onset and progression of chronic kidney disease

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000059416

Enrollment

1600

Registered

2025-10-15

Start date

2025-09-26

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic kidney disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients visiting the Department of Nephrology, Hypertension, and Endocrinology at Nihon University Itabashi Hospital who are diagnosed with chronic kidney disease, or those with diabetes, hypertension, or obesity who are considered to be at high risk of developing chronic kidney disease in the future (from September 2025 to May 2030). 2. healthy individuals who underwent medical checkups at Hatogaya Hospital

Exclusion criteria

Exclusion criteria: 1. Persons who express their unwillingness to participate in this study. 2. Persons deemed by the principal investigator to be unsuitable for inclusion in this study for any reason.

Design outcomes

Primary

Measure	Time frame
Comprehensive protein profiling in blood and urine using Olink Explore HT in patients with CKD or at risk for CKD	—

Secondary

Measure	Time frame
Annual clinical laboratory data (eGFR, Cr, liver function, HbA1c, blood pressure, lipids, CRP, Na, K, renal injury markers, urinary protein, etc.) and imaging examinations (ABI test, cardiac ultrasound, chest X-ray) Effects of concomitant medications on renal function decline based on medical records Associations between multidisciplinary interventions, including nutritional counseling and CKD care guidance, and renal function decline Information on comorbidities (diabetes mellitus, cardiovascular disease, hypertension, etc.) Prognostic information (ESKD, cardiovascular events, death) Baseline information at the time of informed consent (sex, age, medical history, smoking history, body composition, etc.) Measurement of known biomarkers to evaluate their associations with future renal function decline and cardiovascular events Genetic factors analyzed using DNA derived from blood cells RNA and epigenetic markers derived from blood cells Future omics analyses (proteome, transcriptome, epigenome, etc.) using stored biospecimens Circulating non-coding RNAs in blood	—

Measure

Time frame

Annual clinical laboratory data (eGFR, Cr, liver function, HbA1c, blood pressure, lipids, CRP, Na, K, renal injury markers, urinary protein, etc.) and imaging examinations (ABI test, cardiac ultrasound, chest X-ray) Effects of concomitant medications on renal function decline based on medical records Associations between multidisciplinary interventions, including nutritional counseling and CKD care guidance, and renal function decline Information on comorbidities (diabetes mellitus, cardiovascular disease, hypertension, etc.) Prognostic information (ESKD, cardiovascular events, death) Baseline information at the time of informed consent (sex, age, medical history, smoking history, body composition, etc.) Measurement of known biomarkers to evaluate their associations with future renal function decline and cardiovascular events Genetic factors analyzed using DNA derived from blood cells RNA and epigenetic markers derived from blood cells Future omics analyses (proteome, transcriptome, epigenome, etc.) using stored biospecimens Circulating non-coding RNAs in blood

—

Countries

Japan

Contacts

Public ContactHiroki Kobayashi

Nihon University School of Medicine Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine

kobayashi.hiroki@nihon-u.ac.jp+81-3-3972-8111

Outcome results