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Automatic vs Manual Bolus Injection for Thermodilution Assessing Coronary Microvascular Disease

Automatic vs Manual Bolus Injection for Thermodilution Assessing Coronary Microvascular Disease - The AMBITION-CMD Pilot Study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000059382
Enrollment
40
Registered
2025-10-14
Start date
2025-06-11
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Angina with nonobstructive coronary arteries

Interventions

None listed

Sponsors

Department of Cardiology, Sapporo Higashi Tokushukai Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) Patients with symptoms suggestive of angina. 2) Patients without epicardial coronary artery stenosis greater than 50%. 3) Patients suspected of having ANOCA based on criteria 1) and 2), who are scheduled to undergo invasive coronary physiological assessment. 4) Patients aged 20 years or older at the time of consent, regardless of sex. 5) Patients (or legally authorized representatives) who have received a full explanation of the study and have provided written informed consent of their own free will.

Exclusion criteria

Exclusion criteria: 1) Patients with decompensated heart failure. 2) Patients with a history of coronary artery bypass grafting (CABG). 3) Patients with significant valvular heart disease requiring surgical or percutaneous intervention. 4) Patients with coronary anatomy in which guidewire passage is expected to be difficult due to severe tortuosity or other anatomical reasons.

Design outcomes

Primary

MeasureTime frame
To compare the variability in coronary flow reserve (CFR) between two measurements obtained using automatic versus manual saline injection.

Countries

Japan

Contacts

Public ContactYuki Katagiri

Sapporo Higashi Tokushukai Hospital Department of Cardiology

ykatagiri.ggl@gmail.com011-722-1110

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026